Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
  DetailsÜbersicht

Freigegeben
Zeitschriftenartikel

Automated glycan assembly of Lewis type I and II oligosaccharide antigens

MPG-Autoren
/persons/resource/persons209402

Guberman,  Mónica
Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons239941

Bräutigam,  Maria
Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

/persons/resource/persons121849

Seeberger,  Peter H.
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

Externe Ressourcen
Es sind keine externen Ressourcen hinterlegt
Volltexte (beschränkter Zugriff)
Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.
Volltexte (frei zugänglich)

Article.pdf
(Verlagsversion), 2MB

Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Guberman, M., Bräutigam, M., & Seeberger, P. H. (2019). Automated glycan assembly of Lewis type I and II oligosaccharide antigens. Chemical Science, 10(21), 5634-5640. doi:10.1039/c9sc00768g.


Zitierlink: https://hdl.handle.net/21.11116/0000-0004-6271-E
Zusammenfassung
Human blood group related glycan antigens are fucosylated (neo-)lactoseries oligosaccharides that play
crucial roles in pathogenic processes. Lewis type-II-chain antigens mark the surface of cancer cells, but
are also mediators of bacterial infections. To investigate the biological roles of Lewis type glycans a host
of synthetic approaches has been developed. Here, we illustrate how automated glycan assembly (AGA)
using a set of six monosaccharide building blocks provides quick access to a series of more than ten
defined Lewis type-I and type-II antigens, including Lex, Ley, Lea, Leb and KH-1. Glycans with up to three
a-fucose branches were assembled following a strictly linear approach and obtained in excellent
stereoselectivity and purity.