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Genetic diversity of HLA system in two populations from Tamaulipas, Mexico: Ciudad Victoria and rural Tamaulipas

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Barquera,  Rodrigo
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Clayton,  Stephen
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Citation

Rodríguez-Munguía, T. J., Barquera, R., Adalid-Sáinz, C., Hernández-Zaragoza, D. I., Arrieta-Bolaños, E., Clayton, S., et al. (2019). Genetic diversity of HLA system in two populations from Tamaulipas, Mexico: Ciudad Victoria and rural Tamaulipas. Human Immunology. doi:10.1016/j.humimm.2019.07.288.


Cite as: http://hdl.handle.net/21.11116/0000-0004-59D3-A
Abstract
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 148 Mexicans from the state of Tamaulipas living in Ciudad Victoria (N = 23) and rural communities (N = 125), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in the state of Tamaulipas include ten Native American, three European and one African haplotypes. Admixture estimates revealed that the main genetic components in the state of Tamaulipas are Native American (54.69 ± 0.93 by ML; 47.65 of Native American haplotypes) and European (34.66 ± 5.62 by ML; 33.56 of European haplotypes), and a relatively high African genetic component (10.65 ± 5.05 by ML; 12.42 of African haplotypes).