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Genetic diversity of HLA system in two populations from Campeche, Mexico: Campeche city and rural Campeche

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Barquera,  Rodrigo
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Ponnendai-Shanmugavel,  Komathi Sree
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Immel,  Alexander
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Clayton,  Stephen
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Citation

Barquera, R., Lara-Riegos, J., Ponnendai-Shanmugavel, K. S., Immel, A., Arrieta-Bolaños, E., Clayton, S., et al. (2020). Genetic diversity of HLA system in two populations from Campeche, Mexico: Campeche city and rural Campeche. Human Immunology, 81(9), 566-568. doi:10.1016/j.humimm.2019.07.281.


Cite as: http://hdl.handle.net/21.11116/0000-0004-59FB-E
Abstract
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 81 Mexicans from the state of Campeche living in the city of Campeche (N = 34) and rural communities (N = 47), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Campeche include ten Native American, three European, one African and one Asian haplotype. Admixture estimates revealed that the main genetic components in the state of Campeche are Native American (65.56 ± 0.96 by ML; 51.24 of Native American haplotypes), European (34.44 ± 10.94 by ML; 30.25 of European haplotypes), and a virtually absent African genetic component (0.00 ± 10.31 by ML; 9.26 of African haplotypes).