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Genetic diversity of HLA system in two populations from Tabasco, Mexico: Villahermosa and rural Tabasco

MPS-Authors
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Barquera,  Rodrigo
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Ponnendai-Shanmugavel,  Komathi Sree
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Clayton,  Stephen
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

/persons/resource/persons189331

Immel,  Alexander
Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society;

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Citation

Solís-Martínez, R., Barquera, R., Ponnendai-Shanmugavel, K. S., Vega-Martínez, M. d. R., Vázquez-Castillo, T. V., Arrieta-Bolaños, E., et al. (2019). Genetic diversity of HLA system in two populations from Tabasco, Mexico: Villahermosa and rural Tabasco. Human Immunology. doi:10.1016/j.humimm.2019.07.286.


Cite as: https://hdl.handle.net/21.11116/0000-0004-5AED-D
Abstract
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 224 Mexicans from the state of Tabasco living in the city of Villahermosa (N = 82) and rural communities (N = 142), to obtain information regarding allelic and haplotypic frequencies. We found that the most frequent haplotypes in Tabasco include 13 Native American and two European haplotypes. Admixture estimates revealed that the main genetic components in Tabasco are Native American (67.79 ± 1.59 by ML; 56.25 of Native American haplotypes) and European (27.21 ± 3.97 by ML; 29.91 of European haplotypes), and a less prominent African genetic component (5.01 ± 4.42 by ML; 8.93 of African haplotypes).