Impact of insulin signaling and proteasomal activity on physiological output of 
a neuronal circuit in aging Drosophila melanogaster

Augustin, H.; McGourty, K.; Allen, M. J.; Adcott, J.; Wong, C. T.; Boucrot, E.; Partridge, L.

doi:10.1016/j.neurobiolaging.2018.02.027

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Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster

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Partridge, L.
Department Partridge - Biological Mechanisms of Ageing, Max Planck Institute for Biology of Ageing, Max Planck Society;

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https://www.ncbi.nlm.nih.gov/pubmed/29579685
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Citation

Augustin, H., McGourty, K., Allen, M. J., Adcott, J., Wong, C. T., Boucrot, E., et al. (2018). Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster. Neurobiol Aging, 66, 149-157. doi:10.1016/j.neurobiolaging.2018.02.027.

Cite as: https://hdl.handle.net/21.11116/0000-0004-71F3-A

Abstract

The insulin family of growth factors plays an important role in development and function of the nervous system. Reduced insulin and insulin-growth-factor signaling (IIS), however, can improve symptoms of neurodegenerative diseases in laboratory model organisms and protect against age-associated decline in neuronal function. Recently, we showed that chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber escape response circuit. Here, we expand our initial findings by demonstrating that reduced functional output in the giant fiber system of aging flies can be prevented by increasing proteasomal activity within the circuit. Manipulations of IIS in neurons can also affect longevity, underscoring the relevance of the nervous system for aging.