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Abstract

Remembering event sequences is central to episodic memory and presumablysupported by the hippocampal-entorhinal region. We previously demonstrated that thehippocampus maps spatial and temporal distances between events encountered along a routethrough a virtual city (Deuker et al., 2016), but the content of entorhinal mnemonic representationsremains unclear. Here, we demonstrate that multi-voxel representations in the anterior-lateralentorhinal cortex (alEC) — the human homologue of the rodent lateral entorhinal cortex —specifically reflect the temporal event structure after learning. Holistic representations of thesequence structure related to memory recall and the timeline of events could be reconstructedfrom entorhinal multi-voxel patterns. Our findings demonstrate representations of temporalstructure in the alEC; dovetailing with temporal information carried by population signals in thelateral entorhinal cortex of navigating rodents and alEC activations during temporal memoryretrieval. Our results provide novel evidence for the role of the alEC in representing time forepisodic memory.