A biophysical model of iron-induced relaxation in human substantia nigra for 
early stage parkinson diagnostic

Brammerloh, Malte; Lange, Charlotte; Reinert, Tilo; Jäger, Carsten; Gavriilidis, Filippos; Pine, Kerrin; Weigelt, Isabel; Trampel, Robert; Reimer, Enrico; Morawski, Markus; Arendt, Thomas; Weiskopf, Nikolaus; Kirilina, Evgeniya

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Meeting Abstract

A biophysical model of iron-induced relaxation in human substantia nigra for early stage parkinson diagnostic

MPG-Autoren

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Brammerloh, Malte
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Faculty of Physics and Earth Sciences, Leipzig University;

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Reinert, Tilo
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Faculty of Physics and Earth Sciences, Leipzig University;

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Jäger, Carsten
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Gavriilidis, Filippos
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Pine, Kerrin
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Trampel, Robert
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Reimer, Enrico
Department Neurophysics, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Weiskopf, Nikolaus
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Faculty of Physics and Earth Sciences, Leipzig University;

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Kirilina, Evgeniya
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Center for Cognitive Neuroscience Berlin, Freie Universität Berlin;

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Zitation

Brammerloh, M., Lange, C., Reinert, T., Jäger, C., Gavriilidis, F., Pine, K., et al. (2019). A biophysical model of iron-induced relaxation in human substantia nigra for early stage parkinson diagnostic. In Proceedings of the ISMRM 27th Annual Meeting & Exhibition.

Zitierlink: https://hdl.handle.net/21.11116/0000-0004-9C14-6

Zusammenfassung

We present a biophysical model that quantitatively describes gradient and spin echo relaxation in substantia nigra induced by iron accumulated the neuromelanin of dopaminergic neurons. This model was informed by 3D quantitative microscopic iron distributions obtained from classical histology and Proton-Induced X-ray Emission. It was validated by comparison to quantitative MRI on post mortem human brain tissue. We demonstrate that the total iron content of DN can be extracted analytically from relaxometry in nigrosomes. This results provides an important step toward a highly desired early stage biomarker for detecting dopaminergic neurons depletion in Parkinson's disease.