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The neural basis of sign language processing in deaf signers: An activation likelihood estimation meta-analysis


Trettenbrein,  Patrick
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;


Papitto,  Giorgio
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;


Zaccarella,  Emiliano
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;


Friederici,  Angela
Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Trettenbrein, P., Papitto, G., Zaccarella, E., & Friederici, A. (2019). The neural basis of sign language processing in deaf signers: An activation likelihood estimation meta-analysis. Poster presented at 13th Conference of Theoretical Issues in Sign Language Research (TISLR), Hamburg, Germany.

Cite as: http://hdl.handle.net/21.11116/0000-0004-C51C-F
The neurophysiological response during processing of sign language (SL) has been studied since the advent of Positron Emission Tomography (PET) and functional Magnetic Resonance Imaging (fMRI). Nevertheless, the neural substrates of SL remain subject to debate, especially with regard to involvement and relative lateralization of SL processing without production in (left) inferior frontal gyrus (IFG; e.g., Campbell, MacSweeney, & Waters, 2007; Emmorey, 2006, 2015). Our present contribution is the first to address these questions meta-analytically, by exploring functional convergence on the whole-brain level using previous fMRI and PET studies of SL processing in deaf signers. We screened 163 records in PubMed and Web of Science to identify studies of SL processing in deaf signers conducted with fMRI or PET that reported foci data for one of the two whole-brain contrasts: (1) “SL processing vs. control” or (2) “SL processing vs. low-level baseline”. This resulted in a total of 21 studies reporting 23 experiments matching our selection criteria. We manually extracted foci data and performed a coordinate-based Activation Likelihood Estimation (ALE) analysis using GingerALE (Eickhoff et al., 2009). Our selection criteria and the ALE method allow us to identify regions that are consistently involved in processing SL across studies and tasks. Our analysis reveals that processing of SL stimuli of varying linguistic complexity engages widely distributed bilateral fronto-occipito-temporal networks in deaf signers. We find significant clusters in both hemispheres, with the largest cluster (5240 mm3) being located in left IFG, spanning Broca’s region (posterior BA 45 and the dorsal portion of BA 44). Other clusters are located in right middle and inferior temporal gyrus (BA 37), right IFG (BA 45), left middle occipital gyrus (BA 19), right superior temporal gyrus (BA 22), left precentral and middle frontal gyrus (BA 6 and 8), as well as left insula (BA 13). On these clusters, we calculated lateralization indices using hemispheric and anatomical masks: SL comprehension is slightly left-lateralized globally, and strongly left-lateralized in Broca’s region. Sub-regionally, left-lateralization is strongest in BA 44 (Table 1). Next, we performed a contrast analysis between SL and an independent dataset of action observation in hearing non-signers (Papitto, Friederici, & Zaccarella, 2019) to determine which regions are associated with processing of human actions and movements irrespective of the presence of linguistic information. Only studies of observation of non-linguistic manual actions were included in the final set (n = 26), for example, excluding the handling of objects. Significant clusters involved in the linguistic aspects of SL comprehension were found in left Broca’s region (centered in dorsal BA 44), right superior temporal gyrus (BA 22), and left middle frontal and precentral gyrus (BA 6 and 8; Figure 1A, B, D and E). Meta-analytic connectivity modelling for the surviving cluster in Broca’s region using the BrainMap database then revealed that it is co-activated with the classical language network and functionally primarily associated with cognition and language processing (Figure 1C and D). In line with studies of spoken and written language processing (Zaccarella, Schell, & Friederici, 2017; Friederici, Chomsky, Berwick, Moro, & Bolhuis, 2017), our meta-analysis points to Broca’s region and especially left BA 44 as a hub in the language network that is involved in language processing independent of modality. Right IFG activity is not language-specific but may be specific to the visuo-gestural modality (Campbell et al., 2007). 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