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Mapping complementary features of cross-species structural connectivity to construct realistic “virtual brains”

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Ritter,  Petra
Department of Neurology, Charité University Medicine Berlin, Germany;
Minerva Research Group Brain Modes, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Bernstein Center for Computational Neuroscience, Berlin, Germany;
Berlin School of Mind and Brain, Humboldt University Berlin, Germany;

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Citation

Bezgin, G., Solodkin, A., Bakker, R., Ritter, P., & McIntosh, A. R. (2017). Mapping complementary features of cross-species structural connectivity to construct realistic “virtual brains”. Human Brain Mapping, 38(4), 2080-2093. doi:10.1002/hbm.23506.


Cite as: https://hdl.handle.net/21.11116/0000-0004-A979-6
Abstract
Modern systems neuroscience increasingly leans on large-scale multi-lab neuroinformatics initiatives to provide necessary capacity for biologically realistic modeling of primate whole-brain activity. Here, we present a framework to assemble primate brain's biologically plausible anatomical backbone for such modeling initiatives. In this framework, structural connectivity is determined by adding complementary information from invasive macaque axonal tract tracing and non-invasive human diffusion tensor imaging. Both modalities are combined by means of available interspecies registration tools and a newly developed Bayesian probabilistic modeling approach to extract common connectivity evidence. We demonstrate how this novel framework is embedded in the whole-brain simulation platform called The Virtual Brain.