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Coupling of Active Motion and Advection Shapes Intracellular Cargo Transport

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Trong, P. K., Guck, J., & Goldstein, R. E. (2012). Coupling of Active Motion and Advection Shapes Intracellular Cargo Transport. PHYSICAL REVIEW LETTERS, 109(2): 028104. doi:10.1103/PhysRevLett.109.028104.


Cite as: http://hdl.handle.net/21.11116/0000-0004-B3A2-A
Abstract
Intracellular cargo transport can arise from passive diffusion, active motor-driven transport along cytoskeletal filament networks, and passive advection by fluid flows entrained by such cargo-motor motion. Active and advective transport are thus intrinsically coupled as related, yet different representations of the same underlying network structure. A reaction-advection-diffusion system is used here to show that this coupling affects the transport and localization of a passive tracer in a confined geometry. For sufficiently low diffusion, cargo localization to a target zone is optimized either by low reaction kinetics and decoupling of bound and unbound states, or by a mostly disordered cytoskeletal network with only weak directional bias. These generic results may help to rationalize subtle features of cytoskeletal networks, for example as observed for microtubules in fly oocytes.