Modelling the structural response of an eukaryotic cell in the optical stretcher

Ananthakrishnan, R; Guck, Jochen; Wottawah, F; Schinkinger, S; Lincoln, B; Romeyke, M; Kas, J

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Modelling the structural response of an eukaryotic cell in the optical stretcher

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Ananthakrishnan, R., Guck, J., Wottawah, F., Schinkinger, S., Lincoln, B., Romeyke, M., et al. (2005). Modelling the structural response of an eukaryotic cell in the optical stretcher. CURRENT SCIENCE, 88(9), 1434-1440.

Cite as: https://hdl.handle.net/21.11116/0000-0004-B44E-A

Abstract

The cytoskeleton of an eukaryotic cell is a composite polymer material with unique structural (mechanical) properties. To investigate the role of individual cytoskeletal polymers in the deformation response of a cell to an external force (stress), we created two structural models - a thick shell model for the actin cortex, and a three-layered model for the whole cell. These structural models for a cell are based on data obtained by deforming suspended cells, where each cell is stretched between two counter-propagating laser beams using an optical stretcher. Our models, with the data, suggest that the outer actin cortex is the main determinant of the structural response of the cell.