English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Translational recoding: Canonical translation mechanisms reinterpreted.

MPS-Authors
/persons/resource/persons15723

Rodnina,  M. V.
Department of Physical Biochemistry, MPI for Biophysical Chemistry, Max Planck Society;

/persons/resource/persons205650

Korniy,  N.
Department of Physical Biochemistry, MPI for Biophysical Chemistry, Max Planck Society;

/persons/resource/persons206400

Klimova,  M.
Department of Physical Biochemistry, MPI for Biophysical Chemistry, Max Planck Society;

/persons/resource/persons206931

Karki,  P.
Department of Physical Biochemistry, MPI for Biophysical Chemistry, Max Planck Society;

/persons/resource/persons239002

Peng,  B. Z.
Department of Physical Biochemistry, MPI for Biophysical Chemistry, Max Planck Society;

/persons/resource/persons31223

Senyushkina,  T.
Department of Physical Biochemistry, MPI for Biophysical Chemistry, Max Planck Society;

/persons/resource/persons40313

Belardinelli,  R.
Department of Physical Biochemistry, MPI for Biophysical Chemistry, Max Planck Society;

/persons/resource/persons135076

Maracci,  C.
Department of Physical Biochemistry, MPI for Biophysical Chemistry, Max Planck Society;

/persons/resource/persons16047

Wohlgemuth,  I.
Department of Physical Biochemistry, MPI for Biophysical Chemistry, Max Planck Society;

/persons/resource/persons132326

Samatova,  E. N.       
Department of Physical Biochemistry, MPI for Biophysical Chemistry, Max Planck Society;

/persons/resource/persons40304

Peske,  F.
Department of Physical Biochemistry, MPI for Biophysical Chemistry, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

3164556.pdf
(Publisher version), 3MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Rodnina, M. V., Korniy, N., Klimova, M., Karki, P., Peng, B. Z., Senyushkina, T., et al. (2020). Translational recoding: Canonical translation mechanisms reinterpreted. Nucleic Acids Research, 48(3), 1056-1067. doi:10.1093/nar/gkz783.


Cite as: https://hdl.handle.net/21.11116/0000-0004-AD8D-B
Abstract
During canonical translation, the ribosome moves along an mRNA from the start to the stop codon in exact steps of one codon at a time. The collinearity of the mRNA and the protein sequence is essential for the quality of the cellular proteome. Spontaneous errors in decoding or translocation are rare and result in a deficient protein. However, dedicated recoding signals in the mRNA can reprogram the ribosome to read the message in alternative ways. This review summarizes the recent advances in understanding the mechanisms of three types of recoding events: stop-codon readthrough, -1 ribosome frameshifting and translational bypassing. Recoding events provide insights into alternative modes of ribosome dynamics that are potentially applicable to other non-canonical modes of prokaryotic and eukaryotic translation.