A low-molecular-weight ditopic MRI probe for ratiometric sensing of 
zwitterionic amino acid neurotransmitters

Toljić, Đ; Angelovski, G

doi:10.1039/c9cc06463j

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A low-molecular-weight ditopic MRI probe for ratiometric sensing of zwitterionic amino acid neurotransmitters

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Toljić, Đ
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Angelovski, G
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://pubs.rsc.org/en/content/articlepdf/2019/cc/c9cc06463j
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Citation

Toljić, Đ., & Angelovski, G. (2019). A low-molecular-weight ditopic MRI probe for ratiometric sensing of zwitterionic amino acid neurotransmitters. Chemical Communications, 55(79), 11924-11927. doi:10.1039/c9cc06463j.

Cite as: https://hdl.handle.net/21.11116/0000-0004-B6BB-C

Abstract

We report a novel ditopic Gd(III)-based probe selective to zwitterionic amino acid neurotransmitters (ZNTs) crafted for ratiometric MRI imaging. The probe displayed increased binding affinity to ZNTs and non-synchronized concentration-dependent changes of the r1- and r2-relaxivity. Through the application of a T2/T1 weighted MRI strategy, we demonstrated signal enhancement for cooperatively bound glutamate and γ-aminobutyric acid ZNTs over competitive hydrogencarbonate, which remained MR silent.