English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Model-based myocardial T1 mapping with sparsity constraints using single-shot inversion-recovery radial FLASH cardiovascular magnetic resonance.

MPS-Authors
/persons/resource/persons15082

Frahm,  J.
Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society;

Locator
There are no locators available
Fulltext (public)

3165576.pdf
(Publisher version), 4MB

Supplementary Material (public)

3165576_Suppl_1.png
(Supplementary material), 101KB

3165576_Suppl_2.png
(Supplementary material), 150KB

3165576_Suppl_3.docx
(Supplementary material), 14KB

3165576_Suppl_4.avi
(Supplementary material), 31MB

Citation

Wang, X., Kohler, F., Unterberg-Buchwald, C., Lotz, J., Frahm, J., & Uecker, M. (2019). Model-based myocardial T1 mapping with sparsity constraints using single-shot inversion-recovery radial FLASH cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance, 21: 60. doi:10.1186/s12968-019-0570-3.


Cite as: http://hdl.handle.net/21.11116/0000-0004-B91E-B
Abstract
BACKGROUND: This study develops a model-based myocardial T1 mapping technique with sparsity constraints which employs a single-shot inversion-recovery (IR) radial fast low angle shot (FLASH) cardiovascular magnetic resonance (CMR) acquisition. The method should offer high resolution, accuracy, precision and reproducibility. METHODS: The proposed reconstruction estimates myocardial parameter maps directly from undersampled k-space which is continuously measured by IR radial FLASH with a 4 s breathhold and retrospectively sorted based on a cardiac trigger signal. Joint sparsity constraints are imposed on the parameter maps to further improve T1 precision. Validations involved studies of an experimental phantom and 8 healthy adult subjects. RESULTS: In comparison to an IR spin-echo reference method, phantom experiments with T1 values ranging from 300 to 1500 ms revealed good accuracy and precision at simulated heart rates between 40 and 100 bpm. In vivo T1 maps achieved better precision and qualitatively better preservation of image features for the proposed method than a real-time CMR approach followed by pixelwise fitting. Apart from good inter-observer reproducibility (0.6% of the mean), in vivo results confirmed good intra-subject reproducibility (1.05% of the mean for intra-scan and 1.17, 1.51% of the means for the two inter-scans, respectively) of the proposed method. CONCLUSION: Model-based reconstructions with sparsity constraints allow for single-shot myocardial T1 maps with high spatial resolution, accuracy, precision and reproducibility within a 4 s breathhold. Clinical trials are warranted.