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Exchanging water compartments in brain tissue and their impact on proton spin relaxation


Möller,  Harald E.
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Möller, H. E. (2019). Exchanging water compartments in brain tissue and their impact on proton spin relaxation. Talk presented at Educational Symposium: Mechanisms of Longitudinal Relaxation in the Human Brain. Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. 2019-04-11 - 2019-04-11.

Cite as: http://hdl.handle.net/21.11116/0000-0004-BC1A-C
In the confined environment between adjacent myelin membrane layers, water protons experience frequent interactions with non-aqueous components. This accelerates relaxation and induces magnetization transfer (MT) between water and macromolecular protons. For a quantitative analysis, models of varying complexity have been developed. Relatively comprehensive is a model that considers water in an intra-axonal, an extra-axonal and a myelin compartment as well as corresponding macromolecular pools with magnetization transfer and inter-compartmental water exchange as coupling pathways. However, it is far too complex for practical MRI applications, and simpler models are typically used to appreciate the role of myelin for proton relaxation. We will discuss some more frequently employed models in the context of T1, T2, T2* and MT experiments, underlying simplifications and potential limitations.