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Decipher the gliovascular inter-actions with simultaneous fMRI and GCaMP-mediated calcium recordings

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Yu,  X
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Yu, X. (2018). Decipher the gliovascular inter-actions with simultaneous fMRI and GCaMP-mediated calcium recordings. Talk presented at 15th Internaonal Meeting of the European Calcium Society (ECS 2018). Hamburg, Germany. 2018-09-09 - 2018-09-13.


Cite as: http://hdl.handle.net/21.11116/0000-0004-BD3C-5
Abstract
Astrocytes are a key mediator or an indirect effector for brain-state dependent neurovascular coupling. Conventional views consider astrocytes to play critical roles to mediate neurovascular coupling. However, recent studies have shown more evidence that the evoked vasodilation maybe independent of astrocytic activity. In our recent work, we used simultaneous fMRI and cell-type specific calcium recordings to specify a unique linkage of astrocytes with neuronal firing patterns, as well as the whole brain BOLD signal changes. It indicates that astrocytes may play regulatory roles to mediate brain state changes. More detailed causality studies are proposed to specify such novel roles played by astrocytes to mediate brain state fluctuation.