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Meeting Abstract

Iron-induced relaxation mechanisms in the human substantia nigra: Towards quantifying iron load in dopaminergic neurons

MPS-Authors
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Brammerloh,  Malte
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Faculty of Physics and Earth Sciences, Leipzig University;

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Gavriilidis,  Filippos
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Scherf,  Nico
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Weiskopf,  Nikolaus
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Faculty of Physics and Earth Sciences, Leipzig University;

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Kirilina,  Evgeniya
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Center for Cognitive Neuroscience Berlin, Freie Universität Berlin;

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ismrm-2018-abstract.pdf
(Publisher version), 496KB

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Citation

Brammerloh, M., Weigelt, I., Arendt, T., Gavriilidis, F., Scherf, N., Jankuhn, S., et al. (2018). Iron-induced relaxation mechanisms in the human substantia nigra: Towards quantifying iron load in dopaminergic neurons. In Proceedings of the ISMRM 26th Annual Meeting & Exhibition.


Cite as: https://hdl.handle.net/21.11116/0000-0004-C222-A
Abstract
Pathological iron accumulation in the human brain is a biomarker for neurodegeneration. Several diagnostically promising MR-
based methods for in vivo iron quantification were proposed, based on the empirical relationship between R 2 * and iron
concentration. However, these do not account for different chemical forms and cellular distribution of iron. We combined post
mortem MRI, advanced quantitative histology and biophysical modeling to develop a generative theory linking obtained iron
concentrations to quantitative MR parameters. The impact of nanoscale molecular interaction of water with iron and of iron-rich
dopaminergic neurons was quantified in substantia nigra.