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Surface modification of Polydimethylsiloxane by hydrogels for microfluidic applications

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Kemkemer,  Ralf
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Kemkemer, R., Zenghao, Z., Linxiao, Y., Athanasopulu, K., Frey, K., Cui, Z., et al. (2019). Surface modification of Polydimethylsiloxane by hydrogels for microfluidic applications. Current Directions in Biomedical Engineering, 5(1), 93-96. doi:10.1515/cdbme-2019-0024.


Cite as: http://hdl.handle.net/21.11116/0000-0004-BFE8-0
Abstract
In vitro, hydrogel-based ECMs for functionalizing surfaces of various material have played an essential role in mimicking native tissue matrix. Polydimethylsiloxane (PDMS) is widely used to build microfluidic or organ-on-chip devices compatible with cells due to its easy handling in cast replication. Despite such advantages, the limitation of PDMS is its hydrophobic surface property. To improve wettability of PDMS-based devices, alginate, a naturally derived polysaccharide, was covalently bound to the PDMS surface. This alginate then crosslinked further hydrogel onto the PDMS surface in desired layer thickness. Hydrogel-modified PDMS was used for coating a topography chip system and in vitro investigation of cell growth on the surfaces. Moreover, such hydrophilic hydrogel-coated PDMS is utilized in a microfluidic device to prevent unspecific absorption of organic solutions. Hence, in both exemplary studies, PDMS surface properties were modified leading to improved devices.