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Journal Article

Surface modification of Polydimethylsiloxane by hydrogels for microfluidic applications


Kemkemer,  Ralf
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

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Kemkemer, R., Zenghao, Z., Linxiao, Y., Athanasopulu, K., Frey, K., Cui, Z., et al. (2019). Surface modification of Polydimethylsiloxane by hydrogels for microfluidic applications. Current Directions in Biomedical Engineering, 5(1), 93-96. doi:10.1515/cdbme-2019-0024.

Cite as: https://hdl.handle.net/21.11116/0000-0004-BFE8-0
In vitro, hydrogel-based ECMs for functionalizing surfaces of various material have played an essential role in mimicking native tissue matrix. Polydimethylsiloxane (PDMS) is widely used to build microfluidic or organ-on-chip devices compatible with cells due to its easy handling in cast replication. Despite such advantages, the limitation of PDMS is its hydrophobic surface property. To improve wettability of PDMS-based devices, alginate, a naturally derived polysaccharide, was covalently bound to the PDMS surface. This alginate then crosslinked further hydrogel onto the PDMS surface in desired layer thickness. Hydrogel-modified PDMS was used for coating a topography chip system and in vitro investigation of cell growth on the surfaces. Moreover, such hydrophilic hydrogel-coated PDMS is utilized in a microfluidic device to prevent unspecific absorption of organic solutions. Hence, in both exemplary studies, PDMS surface properties were modified leading to improved devices.