A de novo evolved gene in the house mouse regulates female pregnancy cycles

Xie, Chen; Bekpen, Cemalettin; Künzel, Sven; Keshavarz, Maryam; Krebs-Wheaton, Rebecca; Skrabar, Neva; Ullrich, Kristian Karsten; Tautz, Diethard

doi:10.7554/eLife.44392

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A de novo evolved gene in the house mouse regulates female pregnancy cycles

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Xie, Chen
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Bekpen, Cemalettin
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Künzel, Sven
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Keshavarz, Maryam
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Krebs-Wheaton, Rebecca
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Skrabar, Neva
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Ullrich, Kristian Karsten
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Tautz, Diethard
Department Evolutionary Genetics, Max Planck Institute for Evolutionary Biology, Max Planck Society;

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Citation

Xie, C., Bekpen, C., Künzel, S., Keshavarz, M., Krebs-Wheaton, R., Skrabar, N., et al. (2019). A de novo evolved gene in the house mouse regulates female pregnancy cycles. eLife, 8: e44392. doi:10.7554/eLife.44392.

Cite as: https://hdl.handle.net/21.11116/0000-0004-C18A-6

Abstract

The de novo emergence of new genes has been well documented through genomic analyses. However, a functional analysis, especially of very young protein-coding genes, is still largely lacking. Here, we identify a set of house mouse-specific protein-coding genes and assess their translation by ribosome profiling and mass spectrometry data. We functionally analyze one of them, ̑extitGm13030}, which is specifically expressed in females in the oviduct. The interruption of the reading frame affects the transcriptional network in the oviducts at a specific stage of the estrous cycle. This includes the upregulation of ̑extit{Dcpp} genes, which are known to stimulate the growth of preimplantation embryos. As a consequence, knockout females have their second litters after shorter times and have a higher infanticide rate. Given that ̑extit{Gm13030 shows no signs of positive selection, our findings support the hypothesis that a de novo evolved gene can directly adopt a function without much sequence adaptation.