English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse
  1. View item / 
  2. Item Summary

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

Enhancing the biocompatibility of siliconepolycarbonate urethane based implant materials

MPS-Authors
/persons/resource/persons75667

Kemkemer,  Ralf
Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

External Resource

https://www.degruyter.com/downloadpdf/j/cdbme.2019.5.issue-1/cdbme-2019-0114/cdbme-2019-0114.xml
(Any fulltext)

https://doi.org/10.1515/cdbme-2019-0114
(Any fulltext)

Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Athanasopulu, K., Kutuzova, L., Thiel, J., Lorenz, G., & Kemkemer, R. (2019). Enhancing the biocompatibility of siliconepolycarbonate urethane based implant materials. Current Directions in Biomedical Engineering, 5(1), 453-456. doi:10.1515/cdbme-2019-0114.


Cite as: https://hdl.handle.net/21.11116/0000-0004-C1CA-E
Abstract
Polyurethane-bases block copolymers (TPCUs) are block-copolymers with systematically varied soft and hard segments. They have been suggested to serve as material for chondral implants in joint regeneration. Such applications may require the adhesion of chondrocytes to the implant surface, facilitating cell growth while keeping their phenotype. Thus, aims of this work were (i) to modify the surface of soft biostable polyurethane-based model implants (TPCU and TSiPCU) with high-molecular weight hyaluronic acid (HA) using an optimized multistep strategy of immobilization, and (ii) to evaluate bioactivity of the modified TPCUs in vitro. Our results show no cytotoxic potential of the TPCUs. HAbioactive molecules (Mw =700kDa) were immobilized onto the polyurethane surface via polyethylenimine (PEI) spacers, and modifications were confirmed by several characterization methods. Tests with porcine chondrocytes indicated the potential of the TPCU-HA for inducing enhanced cell proliferation.