On the follicular pathway of percutaneous uptake of nanoparticles: Ion 
microscopy and autoradiography studies

Lekki, J.; Stachura, Z.; Dabroś, W.; Stachura, J.; Menzel, F.; Reinert, Tilo; Butz, T.; Pallon, J.; Gontier, E.; Ynsa, M. D.; Moretto, P.; Kertesz, Z.; Szikszai, Z.; Kiss, A. Z.

doi:10.1016/j.nimb.2007.02.021

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On the follicular pathway of percutaneous uptake of nanoparticles: Ion microscopy and autoradiography studies

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Lekki, J., Stachura, Z., Dabroś, W., Stachura, J., Menzel, F., Reinert, T., et al. (2007). On the follicular pathway of percutaneous uptake of nanoparticles: Ion microscopy and autoradiography studies. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 260(1), 174-177. doi:10.1016/j.nimb.2007.02.021.

Cite as: https://hdl.handle.net/21.11116/0000-0004-CED9-0

Abstract

We report on the visualization of the penetration of sunscreen formulations containing TiO2 nanoparticles (about 20 nm primary particle size) into hair follicles of both human and porcine skin using the complementary methods of ion microscopy (PIXE, RBS, STIM) and autoradiography. Particles were found as deep as approx. 400 μm in the follicle, obviously introduced mechanically rather than by a diffusive process. No particles were observed in vital tissue nor in sebaceous glands.