English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Poster

Observing the hyaluronan component of the extracellular matrix in the brain with quantitative MRI

MPS-Authors
/persons/resource/persons127414

Metere,  Riccardo
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons213123

Jäger,  Carsten
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons19864

Möller,  Harald E.
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

External Ressource
No external resources are shared
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Metere, R., Jäger, C., Morawski, M., & Möller, H. E. (2018). Observing the hyaluronan component of the extracellular matrix in the brain with quantitative MRI. Poster presented at Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.


Cite as: http://hdl.handle.net/21.11116/0000-0004-C420-A
Abstract
The tissue composition of the brain can be related to different contrast sources in quantitative MRI. Notably, T1 and T2* strongly correlate with myelin and iron. However, other components may play a role in contrast generation. In particular, the hyaluronan component of the extracellular matrix has been recently proposed as a possible important contributor to MRI contrast. Here, we quantify the bulk contribution of hyaluronan to quantitative relaxation maps. This is obtained by characterizing the evolution of the relevant MRI parameters over time during the enzymatic digestion of the hyaluronan.