Quantifying the myelin and iron contents of the brain in vivo using a linear 
model of relaxation

Metere, Riccardo; Möller, Harald E.

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Quantifying the myelin and iron contents of the brain in vivo using a linear model of relaxation

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Metere, Riccardo
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Möller, Harald E.
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Metere, R., & Möller, H. E. (2018). Quantifying the myelin and iron contents of the brain in vivo using a linear model of relaxation. Poster presented at Joint Annual Meeting ISMRM-ESMRMB 2018, Paris, France.

引用: https://hdl.handle.net/21.11116/0000-0004-C431-7

要旨

Quantitative MRI maps are believed to strongly correlate with myelin and iron contents. Recently, a linear model combining prior information from non-MRI techniques was proposed for quantifying myelin and iron based on relaxometry (R1 and R2*) in post-mortem human brain samples. Here, we propose an adaptation of the linear relaxation model that is capable of predicting (with some limitations) the myelin and iron contents of the brain under in vivo conditions. It uses prior knowledge from the literature to calibrate the linear coefficients and was validated in a cohort of 10 subjects.