Synthetic insulin by selective disulfide bridging, II. polymer phase synthesis 
of the human B chain fragments

Voss, Christoph; Birr, Christian

doi:10.1515/bchm2.1981.362.1.717

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Synthetic insulin by selective disulfide bridging, II. polymer phase synthesis of the human B chain fragments

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Voss, Christoph
Max Planck Institute for Medical Research, Max Planck Society;

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Birr, Christian
Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Voss, C., & Birr, C. (1981). Synthetic insulin by selective disulfide bridging, II. polymer phase synthesis of the human B chain fragments. Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 362(6), 717-725. doi:10.1515/bchm2.1981.362.1.717.

Cite as: https://hdl.handle.net/21.11116/0000-0004-C7BB-9

Abstract

Five protected fragments Ddz-Phe-Val-Asn(Mbh)-Gln(Mbh)-His(Dnp)-Leu-Cys(Acm)-Gly-OH [I], Ddz-Ser(But)-His(Dnp)-Leu-Val-Glu-(OBut)-Ala-OH [II], Ddz-Leu-Tyr(But)-Leu-Val-Cys(Mbzl)-Gly-OH [III], Ddz-Glu(OBut)-Arg(Tos)-Gly-OH [IV], Ddz-Phe-Phe-Tyr(But)-thr(But)-Pro-Lys(Z)-Thr(But)-OH [V] for the synthesis of the human insulin B chain, were prepared by an efficient procedure on solid phase.