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The hexa- and pentapeptide extension of proalbumin II. Processing of specific antibodies against the synthetic hexapaptide

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Birr,  Christian
Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Weigand, K., Birr, C., & Suter, M. (1981). The hexa- and pentapeptide extension of proalbumin II. Processing of specific antibodies against the synthetic hexapaptide. Biochimica et Biophysica Acta: BBA, 670(3), 424-427. doi:10.1016/0005-2795(81)90116-1.


Cite as: http://hdl.handle.net/21.11116/0000-0004-C7DA-6
Abstract
The chemically synthesized proalbumin hexapeptide was coupled to rabbit albumin with carbodiimide. Subsequently rabbits were immunized by subcutaneous injection of the conjugate. After 5 weeks the rabbits had developed antibodies against the hexapeptide, which could be detected by immunodiffusion. A sensitive enzyme-linked immunosorbent assay was developed. Using the hexapeptide and other very similar peptides as antigens, a high specificity of the antibodies against the proalbumin hexapeptide was found.