Aversive state processing in the posterior insular cortex

Gehrlach , Daniel A.; Dolensek , Nejc; Klein, Alexandra S.; Chowdhury , Ritu Roy; Matthys, Arthur; Junghänel, Michaela; Gaitanos, Thomas N.; Podgornik, Alja; Black, Thomas D.; Vaka, Narasimha Reddy; Conzelmann , Karl-Klaus; Gogolla, Nadine

doi:10.1038/s41593-019-0469-1

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Aversive state processing in the posterior insular cortex

MPS-Authors

Gehrlach , Daniel A.
Max Planck Research Group: Circuits for Emotion / Gogolla, MPI of Neurobiology, Max Planck Society;

Dolensek , Nejc
Max Planck Research Group: Circuits for Emotion / Gogolla, MPI of Neurobiology, Max Planck Society;

Klein, Alexandra S.
Max Planck Research Group: Circuits for Emotion / Gogolla, MPI of Neurobiology, Max Planck Society;

Chowdhury , Ritu Roy
Max Planck Research Group: Circuits for Emotion / Gogolla, MPI of Neurobiology, Max Planck Society;

Matthys, Arthur
Max Planck Research Group: Circuits for Emotion / Gogolla, MPI of Neurobiology, Max Planck Society;

Junghänel, Michaela
Max Planck Research Group: Circuits for Emotion / Gogolla, MPI of Neurobiology, Max Planck Society;

Gaitanos, Thomas N.
Max Planck Research Group: Circuits for Emotion / Gogolla, MPI of Neurobiology, Max Planck Society;

Podgornik, Alja
Max Planck Research Group: Circuits for Emotion / Gogolla, MPI of Neurobiology, Max Planck Society;

Black, Thomas D.
Max Planck Research Group: Circuits for Emotion / Gogolla, MPI of Neurobiology, Max Planck Society;

Vaka, Narasimha Reddy
Max Planck Research Group: Circuits for Emotion / Gogolla, MPI of Neurobiology, Max Planck Society;

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Gogolla, Nadine
Max Planck Research Group: Circuits for Emotion / Gogolla, MPI of Neurobiology, Max Planck Society;

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Citation

Gehrlach , D. A., Dolensek , N., Klein, A. S., Chowdhury , R. R., Matthys, A., Junghänel, M., et al. (2019). Aversive state processing in the posterior insular cortex. Nature Neuroscience, 22, 1424-1437. doi:10.1038/s41593-019-0469-1.

Cite as: https://hdl.handle.net/21.11116/0000-0004-D80E-A

Abstract

Triggering behavioral adaptation upon the detection of adversity is crucial for survival. The insular cortex has been suggested to process emotions and homeostatic signals, but how the insular cortex detects internal states and mediates behavioral adaptation is poorly understood. By combining data from fiber photometry, optogenetics, awake two-photon calcium imaging and comprehensive whole-brain viral tracings, we here uncover a role for the posterior insula in processing aversive sensory stimuli and emotional and bodily states, as well as in exerting prominent top-down modulation of ongoing behaviors in mice. By employing projection-specific optogenetics, we describe an insula-to-central amygdala pathway to mediate anxiety-related behaviors, while an independent nucleus accumbens-projecting pathway regulates feeding upon changes in bodily state. Together, our data support a model in which the posterior insular cortex can shift behavioral strategies upon the detection of aversive internal states, providing a new entry point to understand how alterations in insula circuitry may contribute to neuropsychiatric conditions.