Characterisation of three terpene synthases for β-barbatene, β-araneosene and 
nephthenol from social amoebae

Rinkel, J.; Köllner, Tobias G.; Chen, F.; Dickschat, J. S.

doi:10.1039/c9cc07681f

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Characterisation of three terpene synthases for β-barbatene, β-araneosene and nephthenol from social amoebae

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Köllner, Tobias G.
Department of Biochemistry, Prof. J. Gershenzon, MPI for Chemical Ecology, Max Planck Society;

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Citation

Rinkel, J., Köllner, T. G., Chen, F., & Dickschat, J. S. (2019). Characterisation of three terpene synthases for β-barbatene, β-araneosene and nephthenol from social amoebae. Chemical Communications, 55(88), 13255-13258. doi:10.1039/c9cc07681f.

Cite as: https://hdl.handle.net/21.11116/0000-0004-E15E-5

Abstract

The products of three terpene synthases from two social amoebae, Dictyostelium discoideum and Dictyostelium purpureum, were identified, showing sesquiterpene synthase activity for one and diterpene synthase activity for the other two enzymes. Site-directed mutagenesis experiments revealed the importance of a newly identfied highly conserved residue for catalytic activity. For one of the enzyme products, β-araneosene, a bromonium ion induced transannular cyclisation was investigated, yielding the first brominated derivatives of this diterpene.