Conserved amino acid sequence of a neuropeptide, the head activator, from 
coelenterates to humans

Bodenmüller, Heinz; Schaller, H. Chica

doi:10.1038/293579a0

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Conserved amino acid sequence of a neuropeptide, the head activator, from coelenterates to humans

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Bodenmüller, Heinz
Max Planck Institute for Medical Research, Max Planck Society;

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Schaller, H. Chica
Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Bodenmüller, H., & Schaller, H. C. (1981). Conserved amino acid sequence of a neuropeptide, the head activator, from coelenterates to humans. Nature, 293(5833), 579-580. doi:10.1038/293579a0.

Cite as: https://hdl.handle.net/21.11116/0000-0004-E667-5

Abstract

We have recently isolated and sequenced a neuropeptide from the freshwater coelenterate hydra (Hydra attenuata), which was named head activator because it controls head-specific growth and differentiation processes1–4. The head activator is an undecapeptide of molecular weight 1,142, with the sequence pGlu-Pro-Pro-Gly-Gly-Ser-Lys-Val-Ile-Leu-Phe. We have also previously purified a peptide from mammalian brain and intestine which has similar biological and chemical properties to those of the head activator from hydra5,6. Here, we present evidence that a peptide of identical amino acid sequence to the head activator can be isolated from human hypothalamus, bovine hypothalamus and rat intestine. This is the first example of a neuropeptide conserved structurally intact from a most primitive nervous system to the advanced nervous system represented in humans.