Anti-cholesterol triterpenoid acids from Saurauia vulcani Korth. (Actinidiaceae)

Musa, Weny J. A.; Situmeang, Boima; Sianturi, Julinton

doi:10.1080/10942912.2019.1650762

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Anti-cholesterol triterpenoid acids from Saurauia vulcani Korth. (Actinidiaceae)

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Sianturi, Julinton
Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Musa, W. J. A., Situmeang, B., & Sianturi, J. (2019). Anti-cholesterol triterpenoid acids from Saurauia vulcani Korth. (Actinidiaceae). International journal of food properties, 22(1), 1439-1444. doi:10.1080/10942912.2019.1650762.

Cite as: https://hdl.handle.net/21.11116/0000-0005-1F1C-B

Abstract

Two triterpenoid compounds, 3 beta-hydroxy-Olean-12-en- 28-oic acid (1)
and 3,19-Dihydroxyurs-12-en-28-oic acid (2) were isolated from the
leaves of Saurauia vulcani Korth. (Actinidiaceae). The chemical
structures of compounds 1-2 were elucidated with spectroscopic data (UV,
IR, H-1, C-13, DEPT 135o, HMQC, HMBC, H-1-H-1 COSY NMR) and MS as well
as compared with previously reported spectra data. All the compounds
were evaluated for their anti-cholesterol activity by the
Liebermann-Burchard (LB) colorimetric assay. Compound 1-2 showed a
remarkable anti-cholesterol activity. Most importantly, the raised
concentration of 1-2 exhibited a dose-dependent manner. The discoveries
of anti-cholesterol compounds 1-2 were first reported.