Fluid pumping and active flexoelectricity can promote lumen nucleation in cell 
assemblies

Duclut, Charlie; Sarkar, Niladri; Prost, Jacques; Jülicher, Frank

doi:10.1073/pnas.1908481116

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Fluid pumping and active flexoelectricity can promote lumen nucleation in cell assemblies

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Duclut, Charlie
Max Planck Institute for the Physics of Complex Systems, Max Planck Society;

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Jülicher, Frank
Max Planck Institute for the Physics of Complex Systems, Max Planck Society;

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Citation

Duclut, C., Sarkar, N., Prost, J., & Jülicher, F. (2019). Fluid pumping and active flexoelectricity can promote lumen nucleation in cell assemblies. PNAS, 116(39), 19264-19273. doi:10.1073/pnas.1908481116.

Cite as: https://hdl.handle.net/21.11116/0000-0005-1D8F-B

Abstract

We discuss the physical mechanisms that promote or suppress the nucleation of a fluid-filled lumen inside a cell assembly or a tissue. We discuss lumen formation in a continuum theory of tissue material properties in which the tissue is described as a 2-fluid system to account for its permeation by the interstitial fluid, and we include fluid pumping as well as active electric effects. Considering a spherical geometry and a polarized tissue, our work shows that fluid pumping and tissue flexoelectricity play a crucial role in lumen formation. We furthermore explore the large variety of long-time states that are accessible for the cell aggregate and its lumen. Our work reveals a role of the coupling of mechanical, electrical, and hydraulic phenomena in tissue lumen formation.