Antibodies against a preselected peptide recognize and neutralize foot and 
mouth disease virus.

Pfaff, E.; Mussgay, M.; Böhm, H.O.; Schulz, Georg E.; Schaller , H.

doi:10.1002/j.1460-2075.1982.tb01262.x

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Antibodies against a preselected peptide recognize and neutralize foot and mouth disease virus.

MPS-Authors

/persons/resource/persons123190

Schulz, Georg E.
Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society;

External Resource

https://www.embopress.org/doi/epdf/10.1002/j.1460-2075.1982.tb01262.x
(Any fulltext)

https://doi.org/10.1002/j.1460-2075.1982.tb01262.x
(Any fulltext)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Pfaff, E., Mussgay, M., Böhm, H., Schulz, G. E., & Schaller, H. (1982). Antibodies against a preselected peptide recognize and neutralize foot and mouth disease virus. EMBO Journal, 1(7), 869-874. doi:10.1002/j.1460-2075.1982.tb01262.x.

Cite as: https://hdl.handle.net/21.11116/0000-0005-1FC7-9

Abstract

A major antibody combining site on foot and mouth disease virus (FMDV) serotype O1K has been identified in a predicted surface helix of viral protein 1 (VP1) between amino acid residues 144 and 159. A hexadecapeptide covering this sequence elicits high titers of antibodies that specifically recognize and neutralize FMDV. The high quality of the immune response is attributed to a particularly stable conformation of the antigenic amino acid sequence, which is most likely an alpha‐helix.