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Journal Article

Real-time monitoring of solid-phase peptide synthesis using a variable bed glow reactor

MPS-Authors
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Sletten,  Eric T.
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Seeberger,  Peter H.
Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Sletten, E. T., Nuno, M., Guthrie, D., & Seeberger, P. H. (2019). Real-time monitoring of solid-phase peptide synthesis using a variable bed glow reactor. Chemical Communications, 55(97), 14598-14601. doi:10.1039/C9CC08421E.


Cite as: http://hdl.handle.net/21.11116/0000-0005-3E5F-D
Abstract
On-resin aggregation and incomplete amide bond formation are major challenges for solid-phase peptide synthesis that are difficult to be monitored in real-time. Incorporation of a pressure-based variable bed flow reactor into an automated solid-phase peptide synthesizer permitted real-time monitoring of resin swelling to determine amino acid coupling efficiency and on-resin aggregation.