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Assessment of young and aged hematopoietic stem cell activity by competitive serial transplantation assays

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Zhang, Y. W., & Cabezas-Wallscheid, N. (2019). Assessment of young and aged hematopoietic stem cell activity by competitive serial transplantation assays. In Methods in Molecular Biology (pp. 193-203). Springer. doi:10.1007/978-1-4939-9574-5_15.


Cite as: https://hdl.handle.net/21.11116/0000-0005-3A3A-A
Abstract
Healthy hematopoietic stem cells (HSCs) are capable to self-renew and reconstitute the complete hematopoietic system. Upon aging, there is an increased incidence of blood-related diseases. Age-related phenotypes have been widely studied by bone marrow transplantation experiments, where reconstitution of the transplanted cells is a direct measure of HSC activity. In this protocol we describe a competitive bone marrow transplantation assay to functionally test young and old HSCs.