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Journal Article

Immediate brain plasticity after one hour of brain–computer interface (BCI)

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Nierhaus,  Till
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Neurocomputation and Neuroimaging Unit, FU Berrlin, Germany;

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Villringer,  Arno
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany;

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Citation

Nierhaus, T., Vidaurre, C., Sannelli, C., Mueller, K.-R., & Villringer, A. (2021). Immediate brain plasticity after one hour of brain–computer interface (BCI). The Journal of Physiology - London, 599(9), 2435-2451. doi:10.1113/JP278118.


Cite as: http://hdl.handle.net/21.11116/0000-0005-3FED-B
Abstract
A brain‐computer‐interface (BCI) allows humans to control computational devices using only neural signals. However, it is still an open question, whether performing BCI also impacts on the brain itself, i.e. whether brain plasticity is induced. Here, we show rapid and spatially specific signs of brain plasticity measured with functional and structural MRI after only 1 h of purely mental BCI training in BCI‐naive subjects. We employed two BCI approaches with neurofeedback based on (i) modulations of EEG rhythms by motor imagery (MI‐BCI) or (ii) event‐related potentials elicited by visually targeting flashing letters (ERP‐BCI). Before and after the BCI session we performed structural and functional MRI. For both BCI approaches we found increased T1‐weighted MR signal in the grey matter of the respective target brain regions, such as occipital/parietal areas after ERP‐BCI and precuneus and sensorimotor regions after MI‐BCI. The latter also showed increased functional connectivity and higher task‐evoked BOLD activity in the same areas. Our results demonstrate for the first time that BCI by means of targeted neurofeedback rapidly impacts on MRI measures of brain structure and function. The spatial specificity of BCI‐induced brain plasticity promises therapeutic interventions tailored to individual functional deficits, for example in patients after stroke.