Angiotensin II, But Not Norepinephrine and Sodium Nitroprusside, Decreases the 
Renal BOLD Signal

Klarhöfer, M; Schächinger, H; Drewe, J; Scheffler, K

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Angiotensin II, But Not Norepinephrine and Sodium Nitroprusside, Decreases the Renal BOLD Signal

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https://cds.ismrm.org/ismrm-2005/Files/00558.pdf
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Klarhöfer, M., Schächinger, H., Drewe, J., & Scheffler, K. (2005). Angiotensin II, But Not Norepinephrine and Sodium Nitroprusside, Decreases the Renal BOLD Signal. In 13th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2005).

Cite as: https://hdl.handle.net/21.11116/0000-0005-41C8-0

Abstract

Purpose of the study was to evaluate the potential of BOLD fMRI techniques to assess angiotensin II (A2) induced renovascular responsiveness. The effect
of A2 on kidney T2* was compared to the effect of other vasoactive susbstances like sodium nitroprusside (SNP) or norepinephrine (NE). To avoid motion
artifacts and to obtain a good temporal resolution a multi-echo EPI technique was used. A2 caused a shortening of T2* between 6\% and 10\%, whereas
neither SNP nor NE lead to significant changes in T2*. It can be concluded that BOLD MRI is suitable to assess A2-induced responsiveness of the renal vasculature.