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Tonotopic mapping of the mouse auditory midbrain with Mn-enhanced MRI,

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Yu, X., Wadghiri, Y., Sanes, D., & Turnbull, D. (2005). Tonotopic mapping of the mouse auditory midbrain with Mn-enhanced MRI,. In 13th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2005).


Cite as: http://hdl.handle.net/21.11116/0000-0005-41CD-B
Abstract
To examine the spatial sensitivity of Mn-enhanced MRI (MEMRI) for neuronal activity mapping, we detected sound-evoked activity patterns in the auditory midbrain of mice. After mice were exposed to different sound stimuli, and the signal enhancement patterns were compared with tonotopic (iso-frequency) maps derived from electrophysiological recordings. Consistent with the published tonotopic maps of the mouse inferior colliculus (IC), MEMRI revealed that low-to-high frequency components in sound stimuli are encoded in dorsal-to-ventral neuronal populations of the IC. Significantly, MEMRI also provides more elaborate neuronal activity representations corresponding to defined frequency and amplitude components to the acoustic stimulus.