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Meeting Abstract

Compartmental Balloon and BOLD Model


Uludag,  K
Former Department MRZ, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Uludag, K., & Buxton, R. (2005). Compartmental Balloon and BOLD Model. In 13th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2005).

Cite as: http://hdl.handle.net/21.11116/0000-0005-41D6-0
The BOLD effect in response to activation is sensitive to the concentration change of deoxy-Hb, which in turn is dependent on CBF, CBV and CMRO2. To relate these quantities, Buxton et al. proposed a balloon model based on the distensibility of the venous vessels. Here, we develop an extension to the current model in modelling the dynamics of deoxy-Hb and CBV not only in the venous part but in all vascular compartments and their individual intra- and extravascular contributions to the BOLD effect. Thus, the new model can predict outcomes of high-resolution imaging and solve apparent contradictions in experimental data.