Cortical Output Is Gated by Horizontally Projecting Neurons in the Deep Layers

Egger, Robert; Narayanan, Rajeevan T.; Guest, Jason Mike; Bast, Arco; Udvary, Daniel; Messore, Luis F.; Das, Suman; De Kock, Christiaan P.J.; Oberlaender, Marcel

doi:10.1016/j.neuron.2019.10.011

アイテム詳細

登録内容を編集ファイル形式で保存

一時保存へ追加

このアイテムの新しいバージョンが利用可能です:
https://pure.mpg.de/pubman/item/item_3179001_17

詳細要約

公開

学術論文

Cortical Output Is Gated by Horizontally Projecting Neurons in the Deep Layers

MPS-Authors

Egger, Robert
Max Planck Research Group In Silico Brain Sciences, Center of Advanced European Studies and Research (caesar), Max Planck Society;

Narayanan, Rajeevan T.
Max Planck Research Group In Silico Brain Sciences, Center of Advanced European Studies and Research (caesar), Max Planck Society;

/persons/resource/persons249500

Guest, Jason Mike
Max Planck Research Group In Silico Brain Sciences, Center of Advanced European Studies and Research (caesar), Max Planck Society;

Bast, Arco
Max Planck Research Group In Silico Brain Sciences, Center of Advanced European Studies and Research (caesar), Max Planck Society;

Udvary, Daniel
Max Planck Research Group In Silico Brain Sciences, Center of Advanced European Studies and Research (caesar), Max Planck Society;

Messore, Luis F.
Max Planck Research Group In Silico Brain Sciences, Center of Advanced European Studies and Research (caesar), Max Planck Society;

/persons/resource/persons84910

Oberlaender, Marcel
Max Planck Research Group In Silico Brain Sciences, Center of Advanced European Studies and Research (caesar), Max Planck Society;

External Resource

https://www.cell.com/neuron/fulltext/S0896-6273(19)30884-0
(出版社版)

https://www.sciencedirect.com/science/article/pii/S0896627319308840
(出版社版)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

フルテキスト (公開)

1-s2.0-S0896627319308840-main.pdf
(出版社版), 8MB

付随資料 (公開)

There is no public supplementary material available

引用

Egger, R., Narayanan, R. T., Guest, J. M., Bast, A., Udvary, D., Messore, L. F., Das, S., De Kock, C. P., & Oberlaender, M. (2020). Cortical Output Is Gated by Horizontally Projecting Neurons in the Deep Layers. Neuron, 105:, pp. 122-137. doi:10.1016/j.neuron.2019.10.011.

引用: https://hdl.handle.net/21.11116/0000-0005-44B7-0

要旨

Pyramidal tract neurons (PTs) represent the major output cell type of the mammalian neocortex. Here, we report the origins of the PTs’ ability to respond to a broad range of stimuli with onset latencies that rival or even precede those of their intracortical input neurons. We find that neurons with extensive horizontally projecting axons cluster around the deep-layer terminal fields of primary thalamocortical axons. The strategic location of these corticocortical neurons results in high convergence of thalamocortical inputs, which drive reliable sensory-evoked responses that precede those in other excitatory cell types. The resultant fast and horizontal stream of excitation provides PTs throughout the cortical area with input that acts to amplify additional inputs from thalamocortical and other intracortical populations. The fast onsets and broadly tuned characteristics of PT responses hence reflect a gating mechanism in the deep layers, which assures that sensory-evoked input can be reliably transformed into cortical output.

In Brief:
Egger, Narayanan, et al. describe the cellular and circuit mechanisms underlying the transformation of sensory-evoked thalamocortical input into fast and broadly tuned cortical output. The study provides a comprehensive multi-scale cortex model for studying streams of sensory-evoked excitationin silico.