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Journal Article

Traumatic and nontraumatic spinal cord injury: Pathological insights from neuroimaging

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Weiskopf,  Nikolaus
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom;
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Freund,  Patrick
Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland;
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom;
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department of Brain Repair & Rehabilitation, University College London, United Kingdom;
Department of Neurology, University Hospital Zurich, Switzerland;

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Citation

David, G., Mohammadi, S., Martin, A. R., Cohen-Adad, J., Weiskopf, N., Thompson, A., et al. (2019). Traumatic and nontraumatic spinal cord injury: Pathological insights from neuroimaging. Nature Reviews Neurology, 15, 718-731. doi:10.1038/s41582-019-0270-5.


Cite as: https://hdl.handle.net/21.11116/0000-0005-5DC7-3
Abstract
Pathophysiological changes in the spinal cord white and grey matter resulting from injury can be observed with MRI techniques. These techniques provide sensitive markers of macrostructural and microstructural tissue integrity, which correlate with histological findings. Spinal cord MRI findings in traumatic spinal cord injury (tSCI) and nontraumatic spinal cord injury — the most common form of which is degenerative cervical myelopathy (DCM) — have provided important insights into the pathophysiological processes taking place not just at the focal injury site but also rostral and caudal to the spinal injury. Although tSCI and DCM have different aetiologies, they show similar degrees of spinal cord pathology remote from the injury site, suggesting the involvement of similar secondary degenerative mechanisms. Advanced quantitative MRI protocols that are sensitive to spinal cord pathology have the potential to improve diagnosis and, more importantly, predict outcomes in patients with tSCI or nontraumatic spinal cord injury. This Review describes the insights into tSCI and DCM that have been revealed by neuroimaging and outlines current activities and future directions for the field.