BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ 
responses and altered cell mechanics

Hiepen, Christian; Jatzlau, Jerome; Hildebrandt, Susanne; Kampfrath, Branka; Göktas, Melis; Murgai, Arunima; Camacho, Cuellar; Luis, Jose; Haag, Rainer; Ruppert, Clemens; Sengle, Gerhard; Cavalcanti-Adam, Elisabetta Ada; Blank, Kerstin G.; Knaus, Petra

doi:10.1371/journal.pbio.3000557

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BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics

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Göktas, Melis
Kerstin Blank, Mechano(bio)chemie, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Blank, Kerstin G.
Kerstin Blank, Mechano(bio)chemie, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Hiepen, C., Jatzlau, J., Hildebrandt, S., Kampfrath, B., Göktas, M., Murgai, A., et al. (2019). BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics. PLoS Biology, 17(12): e3000557. doi:10.1371/journal.pbio.3000557.

Cite as: https://hdl.handle.net/21.11116/0000-0005-6469-5

Abstract

Balanced TGFβ/BMP-signaling is essential for tissue formation and homeostasis; this study shows that the receptor BMPR2 serves as gatekeeper of this balance, protecting cells from increased TGFβ-responses and integrin-mediated mechanotransduction.