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Site‐Selective Late‐Stage Aromatic [18F]Fluorination via Aryl Sulfonium Salts

MPS-Authors
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Xu,  Peng
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Zhao,  Da
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Berger,  Florian
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Hamad,  Aboubakr
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Rickmeier,  Jens
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Petzold,  Roland
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Kondratiuk,  Mykhailo
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Bohdan,  Kostiantyn
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Ritter,  Tobias
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

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Citation

Xu, P., Zhao, D., Berger, F., Hamad, A., Rickmeier, J., Petzold, R., et al. (2020). Site‐Selective Late‐Stage Aromatic [18F]Fluorination via Aryl Sulfonium Salts. Angewandte Chemie, International Edition, 59(5), 1956-1960. doi:10.1002/anie.201912567.


Cite as: http://hdl.handle.net/21.11116/0000-0005-9176-2
Abstract
Site‐selective functionalization of C−H bonds in small complex molecules is a long‐standing challenge in organic chemistry. Herein, we report a broadly applicable and site‐selective aromatic C−H dibenzothiophenylation reaction. The conceptual advantage of this transformation is further demonstrated through the two‐step C−H [18F]fluorination of a series of marketed small‐molecule drugs.