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Molecular glue concept solidifies

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Baek,  Kheewong
Schulman, Brenda / Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Max Planck Society;

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Schulman,  Brenda
Schulman, Brenda / Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Baek, K., & Schulman, B. (2020). Molecular glue concept solidifies. NATURE CHEMICAL BIOLOGY, 16(1), 2-3. doi:10.1038/s41589-019-0414-3.


Cite as: https://hdl.handle.net/21.11116/0000-0005-73B8-A
Abstract
Molecular-glue-mediated proximity-induced degradation now allows unprecedented therapeutic targeting of previously undruggable proteins. Structures showing how aryl-sulfonamides mediate recruitment of the splicing factor RBM39 to the E3 CRL4(DCAF15) broaden the mechanistic principles by which molecular glues target ubiquitylation.