A cellular-resolution atlas of the larval zebrafish brain

Kunst, Michael; Laurell, Eva; Mokayes, Nouwar; Kramer, Anna; Kubo, Fumi; Fernandes, António M.; Förster, Dominique; Dal Maschio, Marco; Baier, Herwig

doi:10.1016/j.neuron.2019.04.034

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学術論文

A cellular-resolution atlas of the larval zebrafish brain

MPS-Authors

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Kunst, Michael
Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons78306

Laurell, Eva
Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons245322

Mokayes, Nouwar
Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons232651

Kramer, Anna
Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons130026

Kubo, Fumi
Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons208432

Fernandes, António M.
Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons208422

Förster, Dominique
Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons130024

Dal Maschio, Marco
Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society;

/persons/resource/persons39224

Baier, Herwig
Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society;

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1-s2.0-S0896627319303915-main.pdf
(出版社版), 11MB

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引用

Kunst, M., Laurell, E., Mokayes, N., Kramer, A., Kubo, F., Fernandes, A. M., Förster, D., Dal Maschio, M., & Baier, H. (2019). A cellular-resolution atlas of the larval zebrafish brain. Neuron, 103(1), 21-38.e5. doi:10.1016/j.neuron.2019.04.034.

引用: https://hdl.handle.net/21.11116/0000-0005-ACBF-3

要旨

Understanding brain-wide neuronal dynamics requires a detailed map of the underlying circuit architecture. We built an interactive cellular-resolution atlas of the zebrafish brain at 6 days post-fertilization (dpf) based on the reconstructions of over 2,000 individually GFP-labeled neurons. We clustered our dataset in "morphotypes,'' establishing a unique database of quantitatively described neuronal morphologies together with their spatial coordinates in vivo. Over 100 transgene expression patterns were imaged separately and co-registered with the single-neuron atlas. By annotating 72 non-overlapping brain regions, we generated from our dataset an inter-areal wiring diagram of the larval brain, which serves as ground truth for synapse-scale, electron microscopic reconstructions. Interrogating our atlas by "virtual tract tracing'' has already revealed previously unknown wiring principles in the tectum and the cerebellum. In conclusion, we present here an evolving computational resource and visualization tool, which will be essential to map function to structure in a vertebrate brain.