English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Meeting Abstract

Mn-Enhanced MRI of the neonatal mouse brain

MPS-Authors
There are no MPG-Authors available
External Ressource
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Wadghiri, Y., Moreno, C., Yu, X., Joyner, A., & Turnbull, D. (2003). Mn-Enhanced MRI of the neonatal mouse brain. In 11th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2003) (pp. 112).


Cite as: http://hdl.handle.net/21.11116/0000-0005-777C-B
Abstract
Manganese (Mn)-Enhanced MRI (MEMRI) has recently been shown to selectively enhance a number of adult mouse brain regions following subcutaneous injection of MnCl2. We tested the sensitivity of a similar MEMRI approach in the early postnatal mouse brain. Postnatal day 1-10 (P1-P10) mice were injected intra-peritoneally with MnCl2, and imaged after 24-h with 3D T1-weighted spin echo MRI. Compared to previous results in adult mice, we observed maximum MEMRI enhancement in the cerebellum and hippocampus, but not in olfactory bulb or midbrain. MEMRI provides a new approach to image the developing cerebellar foliation patterns in the neonatal mouse.