Mn-Enhanced MRI of the neonatal mouse brain

Wadghiri, YZ; Moreno, C; Yu, X; Joyner, AL; Turnbull, DH

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Mn-Enhanced MRI of the neonatal mouse brain

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https://cds.ismrm.org/ismrm-2003/ismrm03.pdf
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Wadghiri, Y., Moreno, C., Yu, X., Joyner, A., & Turnbull, D. (2003). Mn-Enhanced MRI of the neonatal mouse brain. In 11th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2003) (pp. 112).

Cite as: https://hdl.handle.net/21.11116/0000-0005-777C-B

Abstract

Manganese (Mn)-Enhanced MRI (MEMRI) has recently been shown to selectively enhance a number of adult mouse brain regions following subcutaneous injection of MnCl2. We tested the sensitivity of a similar MEMRI approach in the early postnatal mouse brain. Postnatal day 1-10 (P1-P10) mice were injected intra-peritoneally with MnCl2, and imaged after 24-h with 3D T1-weighted spin echo MRI. Compared to previous results in adult mice, we observed maximum MEMRI enhancement in the cerebellum and hippocampus, but not in olfactory bulb or midbrain. MEMRI provides a new approach to image the developing cerebellar foliation patterns in the neonatal mouse.