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Journal Article

Lipid-dependent coupling of secretory cargo sorting and trafficking at the trans-Golgi network

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von Blume,  Julia
von Blume, Julia / Molecular Basis of Protein Trafficking, Max Planck Institute of Biochemistry, Max Planck Society;

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1873-3468.13552.pdf
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Citation

von Blume, J., & Hausser, A. (2019). Lipid-dependent coupling of secretory cargo sorting and trafficking at the trans-Golgi network. FEBS Letters, 593(17, SI), 2412-2427. doi:10.1002/1873-3468.13552.


Cite as: https://hdl.handle.net/21.11116/0000-0005-8870-3
Abstract
In eukaryotic cells, the trans-Golgi network (TGN) serves as a platform for secretory cargo sorting and trafficking. In recent years, it has become evident that a complex network of lipid-lipid and lipid-protein interactions contributes to these key functions. This review addresses the role of lipids at the TGN with a particular emphasis on sphingolipids and diacylglycerol. We further highlight how these lipids couple secretory cargo sorting and trafficking for spatiotemporal coordination of protein transport to the plasma membrane.