Mn-Enhanced MRI of Neural Activity in the mouse Midbrain

Yu, X; Wadghiri, YZ; Moreno, C; Sanes, DH; Turnbull, DH

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Mn-Enhanced MRI of Neural Activity in the mouse Midbrain

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https://cds.ismrm.org/ismrm-2003/ismrm03.pdf
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Yu, X., Wadghiri, Y., Moreno, C., Sanes, D., & Turnbull, D. (2003). Mn-Enhanced MRI of Neural Activity in the mouse Midbrain. In 11th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2003) (pp. 112).

引用: https://hdl.handle.net/21.11116/0000-0005-7F06-7

要旨

Manganese (Mn)-Enhanced MRI (MEMRI) has been proposed as a method to visualize neuronal activity in animals, taking advantage of the permeability of voltage-gated calcium channels to Mn2+. We tested the sensitivity of MEMRI to detect activation of the mouse auditory system, imaging mice with 3D T1-weighted spin echo MRI at defined time points after intra-peritoneal (IP) injection of MnCl2 and exposure to repetitive auditory stimulation. This easily-implemented protocol resulted in significant (10-15%) MEMRI enhancement in the auditory midbrain, compared to deafened control mice, showing the efficacy of MEMRI for detecting auditory-evoked neural activity in the mouse brain