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Journal Article

The metabolic spectrum of memory T cells

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O'Sullivan,  David
Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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https://onlinelibrary.wiley.com/doi/epdf/10.1111/imcb.12274
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Citation

O'Sullivan, D. (2019). The metabolic spectrum of memory T cells. Immunology and Cell Biology, 97, 636-646. doi:10.1111/imcb.12274.


Cite as: https://hdl.handle.net/21.11116/0000-0005-8259-4
Abstract
The development and persistence of memory T cells are integral to effective host defenses. Cell metabolism has a central role in the maintenance of these populations and engagement of specific metabolic pathways can influence T-cell fate. Nuances in memory T-cell metabolism are both context dependent, and exist, on a spectrum that complements and supports the activity of specific memory T-cell subsets. This review explores how metabolic pathways and substrate choice can influence the phenotype and function of memory T cells.