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Journal Article

The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms


Rink,  J. C.
Department of Tissue Dynamics and Regeneration, MPI for Biophysical Chemistry, Max Planck Society;

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Grohme, M. A., Schloissnig, S., Rozanski, A., Pippel, M., Young, G. R., Winkler, S., et al. (2018). The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms. Nature, 554(7690), 56-61. doi:10.1038/nature25473.

Cite as: https://hdl.handle.net/21.11116/0000-0005-8B9F-C
The planarian Schmidtea mediterranea is an important model for stem cell research and regeneration, but adequate genome resources for this species have been lacking. Here we report a highly contiguous genome assembly of S. mediterranea, using long-read sequencing and a de novo assembler (MARVEL) enhanced for low-complexity reads. The S. mediterranea genome is highly polymorphic and repetitive, and harbours a novel class of giant retroelements. Furthermore, the genome assembly lacks a number of highly conserved genes, including critical components of the mitotic spindle assembly checkpoint, but planarians maintain checkpoint function. Our genome assembly provides a key model system resource that will be useful for studying regeneration and the evolutionary plasticity of core cell biological mechanisms.