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Journal Article

The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms.

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Rozanski,  A.
Department of Tissue Dynamics and Regeneration, MPI for Biophysical Chemistry, Max Planck Society;

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Rink,  J. C.
Department of Tissue Dynamics and Regeneration, MPI for Biophysical Chemistry, Max Planck Society;

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(Supplementary material), 73KB

Citation

Grohme, M. A., Schloissnig, S., Rozanski, A., Pippel, M., Young, G. R., Winkler, S., et al. (2018). The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms. Nature, 554(7690), 56-61. doi:10.1038/nature25473.


Cite as: http://hdl.handle.net/21.11116/0000-0005-8B9F-C
Abstract
The planarian Schmidtea mediterranea is an important model for stem cell research and regeneration, but adequate genome resources for this species have been lacking. Here we report a highly contiguous genome assembly of S. mediterranea, using long-read sequencing and a de novo assembler (MARVEL) enhanced for low-complexity reads. The S. mediterranea genome is highly polymorphic and repetitive, and harbours a novel class of giant retroelements. Furthermore, the genome assembly lacks a number of highly conserved genes, including critical components of the mitotic spindle assembly checkpoint, but planarians maintain checkpoint function. Our genome assembly provides a key model system resource that will be useful for studying regeneration and the evolutionary plasticity of core cell biological mechanisms.