Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Prepontine non-giant neurons drive flexible escape behavior in zebrafish


Marquart,  Gregory D.
Department: Genes-Circuits-Behavior / Baier, MPI of Neurobiology, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

(Publisher version), 3MB

Supplementary Material (public)

(Supplementary material), 142KB


Marquart, G. D., Tabor, K. M., Bergeron, S. A., Briggman, K. L., & Burgess, H. A. (2019). Prepontine non-giant neurons drive flexible escape behavior in zebrafish. PLoS Biology, 17(10): e3000480. doi:10.1371/journal.pbio.3000480.

Cite as: https://hdl.handle.net/21.11116/0000-0005-AF82-3
Many species execute ballistic escape reactions to avoid imminent danger. Despite fast reaction times, responses are often highly regulated, reflecting a trade-off between costly motor actions and perceived threat level. However, how sensory cues are integrated within premotor escape circuits remains poorly understood. Here, we show that in zebrafish, less precipitous threats elicit a delayed escape, characterized by flexible trajectories, which are driven by a cluster of 38 prepontine neurons that are completely separate from the fast escape pathway. Whereas neurons that initiate rapid escapes receive direct auditory input and drive motor neurons, input and output pathways for delayed escapes are indirect, facilitating integration of cross-modal sensory information. These results show that rapid decision-making in the escape system is enabled by parallel pathways for ballistic responses and flexible delayed actions and defines a neuronal substrate for hierarchical choice in the vertebrate nervous system.